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Publications & Presentations (Selected)

Refereed Journals

“Association of common variations in the norepinephrine transporter gene with response to Olanzapine/Fluoxetine combination versus continued-fluoxetine treatment in patients with treat-resistant depression: a candidate gene analysis”, J. Houston, K. Lau, V. Aris, W. Liu, B. Fijal, A. Heinloth, R. Perlis, J. Clinical Psychiatry, Vol. 73 (6), p. 878, 2012


“Risk estimation of distant metastasis in node-negative, estrogen receptor-positive breast cancer patients using an RT-PCR based prognostic expression signature”, A. Tutt, A. Wang, C. Rowland, C. Gillett, K. Lau, K. Chew, H. Dai, S. Kwok, K. Ryder, H. Shu, R. Springall, P. Cane, B. McCallie, L. Kam-Morgan, S. Anderson, H. Buerger, J. Gray, J. Bennington, L. Esserman, T. Hastie, S. Broder, J. Sninsky, B. Brandt, F. Waldman, BMC Cancer, 8:339, 2008


“Confidence intervals for predictive values using data from a case control study”, N. Mercaldo, K. Lau, X.H. Zhou, Statistics in Medicine, Vol. 26, p. 2170, 2007


“Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease”, Y. Li, P.Hollingworth, P. Moore, C. Foy, N. Archer, J. Powell, P. Nowotny, P. Holmans, M. O’Donovan, K. Tacy, L. Doil, R. van Luchene, V. Garcia, C. Rowland, K. Lau, J. Cantanese, J. Sninsky, J. Hardy, L. Thal, J. Morris, A. Goate, S. Lovestone, M. Owen, J. Williams, and A. Grupe, Human Mutation, Vol. 25, p.270, 2005


“Association of late-onset Alzheimer’s disease with genetic variation in multiple members of the GAPD gene family”, Y. Li, P. Nowotny, P. Holmans, S. Smemo, J. Kauwe, A. Hinrichs, K. Tacey, L. Doil, R. van Luchene, V. Garcia, C. Rowland, S. Schrodi, D. Leong, G. Gogic, J. Chan, A. Cravchik, D. Ross, K. Lau, S. Kwok, S-Y Chang, J. Cantanese, J. Sninsky, T. White, J. Hardy, J. Powell, S. Lovestone, J. Morris, L. Thal, M. Owen, J. Williams, A. Goate, and A. Grupe, PNAS, Vol. 101, p. 15688, 2004


“Association of ABCA1 with late-onset Alzheimer’s disease is not observed in a case-control study”, Y. Li, K. Tacey, L. Doil, R. van Luchene, V. Garcia, C. Rowland, S. Schrodi, D. Leong, K. Lau, J. Cantanese, J. Sninsky, P. Nowotny, P. Holmans, J. Hardy, J. Powell, S. Lovestone, L. Thal, M. Owen, J. Williams, A. Goate, A. Grupe, Neuroscience Letters, Vol. 366, p. 268, 2004


“Alpha-T-catenin is expressed in human brain and interacts with the wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer’s disease”, V. Busby, S. G. Goosens, P. Nowotny, G. Hamilton, S. Smemo, D. Harold, D. Turic, L. Jehu, A. Myers, M. Womick, D. Wood, D. Compton, L. Doil, K. Tacey, K. Lau, S. Al-Saraj, R. Killick, S. Pickering-Brown, P. Moore, P. Hollingworth, N. Archer, C. Foy, S. Walter, C. Lendon, T. Iwatsubo, J. Morris, D. Mann, B. Janssens, J. Hardy, M. O’Donovan, L. Jones, J. Williams, P. Holmans, M. Own, A. Grupe, J. Powell, J. van Hengel, A. Goate, F. van Roy, S. Lovestone., Neuromolecular Medicine, Vol. 5 (2), p. 133, 2004.


“Genome-tagged Mice (GTM): two sets of genome-wide congenic strains,” O.A. Iakoubova, C.L. Olsson, K.M. Dains, D. Ross, A. Andalibi, K.F. Lau, J. Choi, I. Kalcheva, M. Cunanan, J. Louie, V. Nimon, M. Machrus, C. Beauheim, S. Silvey, J. Cavalcoli, A.J. Lusis, D.B. West, Genomics, Vol. 74 (1), p. 89, 2001.


“A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort,” J. Hampe, S. Schreiber, S.H. Shaw, K.F. Lau, S. Bridger, A.J.S. Macpherson, L.R. Cardon, H. Sakul, T. Harris, A. Buckler, J. Hall, P. Stokkers, S.J.H. van Deventer, P. Nurnberg, M.M. Mirza, J.C.W. Lee, J.E. Lennard-Jones, C. Mathew, M. Curran, Am. J. Hum. Genet. , Vol. 64, No. 3, p.808, 1999


“Genetic analysis of inflammatory bowel disease in a large European cohort supports linkage to chromosomes 12 and 16,” M. Curran, K.F. Lau, J. Hampe, S. Schreiber, S.Bridger, A.J.S. Macpherson, L.R. Cardon, H. Sakul, T. Harris, P. Stokkers, S.J.H. van Deventer, M. Mirza, A. Raedler, W. Kruis, U. Meckler, D. Theuer, T. Herrmann, P. Gionchetti, J. Lee, C. Mathew, and J. Lennard-Jones, Gastroenterology, Vol. 115, p.1066, 1998


“Effects of switching functions on the behavior of liquid water in molecular dynamics simulations,” K. F. Lau, H.E. Alper, T.S. Thacher and T.R. Stouch, J. Phys. Chem., Vol. 98, No. 35, p. 8785, 1994 “Theory for protein mutability and biogenesis,” K.F. Lau and K.A. Dill, Proc. Natl. Acad. Sci. USA, Vol. 87, p. 638, 1990.


“A lattice statistical mechanics model of the conformational and sequence spaces of proteins,” K.F. Lau and K.A. Dill, Macromolecules, Vol. 22, p. 3986, 1989


Review Articles

“Pharmacogenetics”, K.F. Lau and H. Sakul, Annual Reports in Medicinal Chemistry, Vol. 35, Chapter 23, p. 261, 2000


Technical Reports

“Clinical evaluation for reproducibility of the Celera Diagnostics cystic fibrosis genotyping assay – statistical analysis”, K.F. Lau, 2006, Celera Diagnostics.


“Probit analyses to determine 95% limit of detection in HCV assays”, K.F. Lau, 2006, Celera Diagnostics. “Evaluation of the Abbott genetic prediction model for the stillbirth endpoint in the BIDMC study”, C. Rowland, R. Venkatesh, K.F. Lau, 2005, Celera Diagnostics.


“HCV CE quantification project report”, A. Jacobson and K.F. Lau, 2004, Celera Diagnostics.


“Sample size considerations for pharmacogenetic experiments in clinical trials with continuous endpoints”, K.F. Lau, J. Wang, H. Sakul, R.C. Elston, 2001, Parke-Davis.


Conference Presentations

“Time dependence of gene-expression signatures to predict breast cancer recurrence”, K.F. Lau. Poster presentation in Joint Statistical Meeting, August 2012


“Statistical pharmacogenomics studies in data services CRO and biotech”, K.F. Lau. Oral Presentation in Joint Statistical Meeting, August 2011


“Association Between SNPs in SLC6A2 and COMT and Response to LY2216684 In Patients with Major Depressive Disorder”, L. Nisenbaum, K.F. Lau, S. Dharia, L. Marangell, L. Munsie, B. Fijal, M.A. Dellva, K. Merchant, S. Dube. Poster presentation in 49th Annual Meeting of American College of Neuropsychopharmacology, Florida, December 2010


“Time dependence of prognostic values of gene-expression signatures for breast cancer”, K.F. Lau, Poster presentation in the 2009 Annual Meeting of American Society of Clinical Oncologist, May 2009


“Time dependence of an RT-PCR multi-gene prognostic signature to predict distant-metastasis-free survival (DMFS) in node-negative (N-), ER-positive (ER+) breast cancer patients”, K.F. Lau, A. Tutt, A. Wang, C. Gillett, K. Chew, S. Broder, F. Waldman, T. Hastie, J. Sninsky. Oral presentation in 6th Biennial Meeting of Asian Breast Cancer Society, Hong Kong, September, 2007


“An RT-PCR-based multi-gene prognostic signature predicts distant metastasis in both treated and untreated node-negative (N-), ER-positive (ER+) breast cancer from FFPE sections”, K. Lau, A. Wang, K. Chew, H. Dai, C. Liedtke, T. Hastie, J. Sninsky, F. Waldman, B. Brandt. Poster presentation in American Society of Clinical Oncologist Breast Cancer Symposium, September 2007


“Time dependence of a gene-expression prognosticator from modeling breast cancer survival data”, K.F. Lau, J. Sninsky, T. Hastie. Oral presentation in Joint Statistical Meeting, August, 2007


“A gene expression signature predicts distant metastasis in both treated and untreated node-negative and ER-positive breast cancer patients using FFPE samples”, K.F. Lau, A. Wang, H. Shu, B. McCallie, U. Vogt, H. Buerger, C. Liedtke, J. Sninsky, B. Brandt. Poster presentation in AACR Oncogenomics , February 2007


“Prediction modeling using survival data for gene expression prognostic test for breast cancer”, K.F. Lau, A. Wang, J. Sninsky, T. Hastie. Oral presentation in Topic Contributed Session organized by Statistics Department of CDRH, FDA for Joint Statistical Meeting, August, 2006


“An RT-PCR-based multi-gene prognostic signature predicts distant metastasis of node negative, ER positive breast cancer from FFPE sections”, K.F. Lau, A. Wang, K. Chew, H. Dai, T. Hastie, B. Brandt, F. Waldman, J. Sninsky. Oral presentation in the 2006 Annual Meeting of American Society of Clinical Oncologists, June, 2006


“An RT-PCR-based multi-gene prognostic signature predicts distant metastasis of node negative, ER positive breast cancer from FFPE sections”, K.F. Lau, A. Wang, K. Chew, H. Dai, T. Hastie, B. Brandt, F. Waldman, J. Sninsky. Poster presentation in the 11th Society of Chinese Bioscientists in America (SCBA) International Symposium, July, 2006


“Assessment of hormone receptor status in breast cancer by immunohistochemical and gene expression assays”, A. Wang, K. Chew, S.Y. Chang, K.F. Lau, C. Santani, T. Vess, M. Eisenberg, J. Benington, S. Anderson, J. Sninsky, F. Waldman, J. Hessling. Poster presentation in the first AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development, September, 2006.


“Diplotype analyses for genetic association of Insulin Degrading Enzyme (IDE) gene with Late Onset Alzheimer’s Disease (LOAD)”, C. Rowland, K. Tacey, L. Doil, V. Garcia, P. Nowotny, S. Smemo, J. Morris, L. Thal, M. Owen, J. Williams, A. Grupe, A. Goate, K.F. Lau. Poster presentation in 9th International Conference on Alzheimer’s Disease and Related Disorder, July, 2004


“Multivariate diplotype analyses in genetic association studies – association of Insulin Degrading Enzyme (IDE) gene with Late Onset Alzheimer’s Disease (LOAD)”, K.F. Lau, C. Rowland, A. Grupe, A. Goate, J. Morris. Poster presentation in Annual Meeting of American Society of Human Genetics, Los Angeles, CA, Nov., 2003


“Prognosis of Breast Cancer Patients by Gene Expression Profiling Using a Small Set of Genes from Novel Statistical Analyses”, E. Bair, A. Wang, K. Chew, K.F. Lau, J. Gray, S.Y. Chang, B. Brandt, F. Waldman, J. Sninsky. Oral and poster presentation in 24th Congress of the International Association for Breast Cancer Research: Advances in Human Breast Cancer Research, Sacramento, CA, Nov. 1 – 5, 2003


Invited Talks

“Bioinformatics: Recent Developments for Advancing Medicine”, keynote speaker in Nansha Science and Technology Forum: Bioinformatics and Future Medicine, August, 2006, China.


“Molecular Diagnostics and Persnonalized Medicine: Genomics, Statistics, and Bioinformatics”, invited talk to Thailand National Science and Technology Development Agency in August 2006, Thailand.